Table 4 Effects of intravenous bolus injection of SET-M33 at 0 (vehicle = 0.9% saline solution), 5, 9 and 15 mg/kg on body temperature, locomotor activity and body weight in male rats (group mean values ± standard deviation).
From: Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs
Dose (mg/kg) | Group mean body temperature (°C ± sd) at time post-dose | Group mean locomotor activity (# ± sd) at time post-dose: | Group mean bodyweight (g ± sd) on day | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pre-dose | 5 min | 30 min | 90 min | 240 min | 24 h | Pre-dose | 5 min | 30 min | 90 min | 240 min | 24 h | 1 | 2 | 3 | 7 | |
0 | 37.3 | 38 | 37.4 | 37.1 | 36.6 | 36.9 | 44.8 | 39.3 | 28.8 | 27.8 | 16 | 35 | 204.5 | 206 | 210.7 | 229 |
± 0.26 | ± 0.36 | ± 0.25 | ± 0.45 | ± 0.41 | ± 0.38 | ± 6.77 | ± 10.46 | ± 10.38 | ± 5.64 | ± 7.29 | ± 8.65 | ± 6.72 | ± 8.79 | ± 9.07 | ± 12.03 | |
5 | 37.5 | 37.9 | 37.2 | 36.9 | 36.9 | 37.1 | 37.8 | 30.7 | 26.5 | 24.2 | 22.5 | 30 | 207.2 | 209 | 215.8 | 236.5 |
± 0.31 | ± 0.27 | ± 0.51 | ± 0.29 | ± 0.48 | ± 0.51 | ± 9.56 | ± 6.56 | ± 7.12 | ± 6.71 | ± 5.05 | ± 15.02 | ± 2.79 | ± 3.22 | ± 3.87 | ± 8.17 | |
9 | 37.5 | 37.6* | 37.3 | 36.9 | 36.7 | 36.8 | 38.2 | 32.5 | 27 | 21.3 | 22.5 | 28.3 | 204.8 | 201.2 | 209.5 | 229.5 |
± 0.34 | ± 0.31 | ± 0.43 | ± 0.35 | ± 0.41 | ± 0.79 | ± 7.73 | ± 5.96 | ± 9.34 | ± 12.65 | ± 12.82 | ± 12.82 | ± 4.92 | ± 4.36 | ± 3.39 | ± 5.01 | |
15 | 37.2 | 37.4** | 36.9 | 36.9 | 36.7 | 36.9 | 38.3 | 22.2** | 29 | 20.7 | 18.5 | 25.5 | 206 | 200.3 | 209.7 | 227 |
± 0.51 | ± 0.29 | ± 0.41 | ± 0.24 | ± 0.31 | ± 0.5 | ± 4.08 | ± 9.5 | ± 5.8 | ± 8.02 | ± 8.17 | ± 10.21 | ± 5.93 | ± 6.92 | ± 7.58 | ± 8.34 | |
