Figure 7 | Scientific Reports

Figure 7

From: β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo

Figure 7

Anti-inflammatory characterization of the BCP-DHA treatment in the face of MRSA infection. The recognition of S. aureus by toll-like receptors present in the cell membrane initiates an intracellular signaling cascade that results in the dissociation of the NF-κB/Iκb complex, NF-κB translocation to the cell nucleus, and stimulation of the synthesis of pro-inflammatory cytokines. BCP-DHA treatment acts through inhibiting different pathways that result in the activation of NF-κB, negatively regulating the expression of the MD2, IRF7, NLRP3, and TYK2 genes, which culminates in lower synthesis and acting of pro-inflammatory cytokines.

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