Table 1 Blood gases, pH and lactate levels.

From: Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock

 

Fresh blood (FB)

PolyhHb

Stored blood (SB)

pCO2 (mmHg)

BL

48.8 ± 2.9

50.5 ± 1.8

53.3 ± 5.7

Shock 50 min

41.9 ± 1.8

43.5 ± 1.5

45.6 ± 3.9

Resus 15 min

44.2 ± 2.3

40.5 ± 2.1

49.9 ± 3.2

Resus 2 h

38.8 ± 1.9

29.6 ± 1.3

36.3 ± 3.0

Resus 24 h

36.0 ± 2.8

39.0 ± 1.0

37.1 ± 1.9

pO2 (mmHg)

BL

107.4 ± 3.8

88.6 ± 10.6

108.6 ± 5.8

Shock 50 min

106.2 ± 2.8

92.1 ± 8.6

103.9 ± 5.5

Resus 15 min

95.1 ± 5.8

88.3 ± 9.5

98.7 ± 4.1

Resus 2 h

82.0 ± 6.7

84.1 ± 7.9

82.2 ± 6.4

Resus 24 h

75.2 ± 8.5

72.3 ± 3.6

67.3 ± 6.8

pH

BL

7.262 ± 0.033

7.290 ± 0.016

7.199 ± 0.068

Shock 50 min

7.316 ± 0.044

7.313 ± 0.017

7.355 ± 0.043

Resus 15 min

7.343 ± 0.032

7.341 ± 0.021

7.341 ± 0.037

Resus 2 h

7.435 ± 0.018

7.429 ± 0.019

7.445 ± 0.034

Resus 24 h

7.436 ± 0.017

7.456 ± 0.017

7.449 ± 0.015

Lactate (mmol/L)

BL

1.94 ± 0.75

1.47 ± 0.39

1.63 ± 0.39

Shock 50 min

3.56 ± 1.18

2.66 ± 0.47

2.07 ± 0.38

Resus 15 min

1.86 ± 0.78

1.90 ± 0.39

1.23 ± 0.19

Resus 2 h

0.76 ± 0.04

2.52 ± 0.57

0.87 ± 0.17

Resus 24 h

1.08 ± 0.48

1.19 ± 0.16

0.67 ± 0.03

  1. All resuscitation solutions preserved blood gases and pH within physiological ranges after resuscitation from HS. Moreover, all resuscitation solutions restored lactate to normal levels 24 h after resuscitation. Animals were awake at the 2 h and 24 h timepoints. Data was presented as the mean ± SE. BL (Baseline); HS (Hemorrhagic Shock); Resus (Resuscitation). No statistical differences were detected between groups in blood gases, blood pH, or blood lactate. Statistical comparisons were completed using a two way-ANOVA; Tukey’s multiple comparison test.
Back to article page