Table 2 C-kit exon 8,11 and 17 mutations detected in the present cohort of Acute myeloid leukemia (n = 31).

From: Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients

Sr #

Patient ID

Gender M/F

Age (Yrs)

Cyt. Abnl

FAB type

Mutation detected in cKit Exon

Nucleotide Change

Aminoacid change

Reported by

1

INM2

F

30

n/a

M2

08

1279A > G

Arg420Gly

Novel

11

1684T > A

Val555Glu

17

2

INM3

M

40

n/a

M5

08

1279

A > G

Arg420Gly

Novel

3

INM4

M

27

n/a

M6

08

Insertion of G at 1282, 1289 and 1294

Amino acid frameshift

Novel

4

INM5

F

24

T(8;21)

M2

08

1279A > G

Arg420Gly

Novel

5

INM6

M

34

n/a

M4

08

Insertion of G at 1280, 1289 and 1295

Amino acid frameshift

Novel

6

INM7

M

21

n/a

M1

08

1279A > G

Arg420Gly

Novel

Insertion of T at 1287

Amino acid frameshift

Novel

7

INM8

F

29

n/a

M4

08

1279A > G

Arg420Gly

Novel

8

INM10

F

17

T(8;21)

M2

08

Insertion of T at 1325

Amino acid frameshift

Novel

11

1684T > A

Val555Glu

17

17

2415C > T

Ile798Ile

18

9

JIN21

M

38

n/a

M6

08

Insertion of G at 1292

Amino acid frameshift

Novel

17

2415C > T

Ile798Ile

18

10

JIN22

M

52

n/a

M5

08

Insertion of G at 1280 and 1288

Amino acid frameshift

Novel

11

JIN24

M

52

n/a

M1

08

Insertion of G at 1291 and 1297

Amino acid frameshift

Novel

12

JIN25

M

18

n/a

M5

08

1279A > G

Arg420Gly

Novel

13

JIN26

M

18

n/a

M5

08

1279A > G

Arg420Gly

14

JIN27

M

47

n/a

M4

08

1279A > G

Arg420Gly

15

JIN28

M

25

n/a

M2

08

1279A > G

Arg420Gly

  1. M Male, F Female, Yrs Years, n/a not any, Cyt.Abnl Cytogenetic abnormality, FAB French American British classification.
Back to article page