Table 1 Analysis of cytotoxicity and trypanocidal effect of FEX.

From: Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi

IC50 (µM) T. cruzi

Epimastigote

IC50 (µM) T. cruzi

Amastigote

SI

LD50 (µM) T. cruzi Trypomastigote

SI

CC50 (µM)

LLC-MK2

24 h

48 h

72 h

72 h

24 h

96 h

40 ± 10 µM

30 ± 10 µM

23 ± 3 µM

1 ± 0.5 µM

80

50 ± 2 µM

1.6

80 ± 10 µM

  1. IC50: concentration that inhibits 50% of the proliferation of the replicative form.
  2. LD50: concentration that causes lysis in 50% of the trypomastigotes.
  3. CC50: concentration that inhibits the proliferation of host cells by 50%.
  4. SI: selectivity index.
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