Figure 3 | Scientific Reports

Figure 3

From: Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers

Figure 3The alternative text for this image may have been generated using AI.

The viability of mouse fibroblast (3T3) and human keratinocyte (HaCaT) cell lines (A, B, respectively) determined using NR and MTT assays after 48 h of incubation with the selected enhancers Pro2, Pro3, and Pro4. Data are presented as the means ± SEM; n ≥ 3. (C) Morphological changes of 3T3 and HaCaT cells treated with low (IC15) and high (IC85) doses of Pro3 (others shown in Supplementary Figure S1). Cells were stained for nuclei (blue), microfilaments (green), and microtubules (red). The bar represents 200 µm.

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