Table 1 Cohort of deliveries with and without medication exposure to repurposed medications.
No medication exposure (N = 60,504) | Medication exposure (N = 2,830) | Total distinct deliveries (N = 63,334) | ||||
|---|---|---|---|---|---|---|
N | % | N | % | N | % | |
Pregnancy outcome | ||||||
Cesarean section | 19,856 | 32.82 | 1038 | 36.68 | 20,894 | 32.99 |
Preterm birth | 3601 | 5.95 | 296 | 10.46 | 3897 | 6.15 |
Stillbirth | 487 | 0.80 | 29 | 1.02 | 516 | 0.81 |
Comorbidities for adjustment | ||||||
Adverse drug | 27 | 0.04 | * | 0.32 | 36 | 0.06 |
Autoimmune | 27 | 0.04 | 18 | 0.64 | 45 | 0.07 |
Cancer | 312 | 0.52 | 85 | 3.00 | 397 | 0.63 |
Cardiovascular | 411 | 0.68 | 202 | 7.14 | 613 | 0.97 |
Cerebrovascular | * | <0.01 | * | 0.11 | * | 0.01 |
Circulatory | 18 | 0.03 | 29 | 1.02 | 47 | 0.07 |
Infectious disease | 965 | 1.59 | 290 | 10.25 | 1255 | 1.98 |
Maternal care | 214 | 0.35 | 50 | 1.77 | 264 | 0.42 |
Medication allergy | 231 | 0.38 | 79 | 2.79 | 310 | 0.49 |
Multiple birth | 1415 | 2.34 | 147 | 5.19 | 1562 | 2.47 |
Obesity | 892 | 1.47 | 209 | 7.39 | 1101 | 1.74 |
Obstetric history | 121 | 0.20 | 61 | 2.16 | 182 | 0.29 |
Organ transplant/acquired absence | 20 | 0.03 | 18 | 0.64 | 38 | 0.06 |
Preeclampsia | 4718 | 7.80 | 353 | 12.47 | 5071 | 8.01 |
Procedure | 173 | 0.29 | 45 | 1.59 | 218 | 0.34 |
Respiratory | 54 | 0.09 | 118 | 4.17 | 172 | 0.27 |
Toxic effect | * | < 0.01 | * | 0.07 | * | 0.01 |
Mean maternal age +/− standard deviation | 29.46 ± 6.07 | 29.67 ± 6.28 | 29.48 ± 6.08 | |||
