Figure 3
From: Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events
Receiver Operator Characteristic Curve for discrimination of HFpEF in CATHGEN. Shown are four Receiver Operator Characteristic (ROC) curves for discrimination of HFpEF with NT-proBNP alone, the addition of the clinical adjusted clinical model (age, race, body mass index (BMI), systolic blood pressure (SBP), type 2 diabetes mellitus (DM) and creatinine) and the addition of both the 20 validating protein model and the LASSO with Monte Carlo cross-validation 13-protein biomarker model. The 20 validating proteins are: LCN2, U-PAR, IL-1ra, KIM1, CSTB, Gal-9, TIMP-1, MATN2, XCL1, NEMO, CRELD2, MMP7, SUMF2, TXNDC5, PRELP, TMSB10, CDH2, PARP-1, SPINT2, FCGR3B. The 13 LASSO selected proteins were AOC3, CA5A, CA6, CCL16, CLSTN2 , Gal-9, IGFBP3, KIM1, NEMO, PSGL-1, SERPINA12, SUMF2, VEGFD. The addition of either the 20 or 13-protein model to the adjusted model and NT-proBNP improved the discriminative capabilities of the model.
