Table 2 Proteins associated with HFpEF in both discovery CATHGEN and validation TECOS multivariate models.
From: Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events
Protein | CATHGEN discovery cohort | TECOS validation cohort | ||||
|---|---|---|---|---|---|---|
Univariate model | Multivariate model* | Multivariate model† | ||||
OR (95% CI) | p; FDR | OR (95% CI) | p | OR (95% CI) | p | |
LCN2 | 2.92 (1.59–5.42) | 6.1 × 10–4; 3.6 × 10–3 | 2.77 (1.29–6.05) | 0.01 | 2.58 (1.38–5.17) | 4.4 × 10–3 |
U-PAR | 3.06 (2.01–4.95) | 1.1 × 10–6; 7.6 × 10–5 | 2.39 (1.44–4.18) | 1.1 × 10–3 | 1.95 (1.06–3.85) | 0.04 |
IL-1ra | 1.92 (1.38–2.72) | 1.7 × 10–4; 1.3 × 10–3 | 2.06 (1.32–3.35) | 2.2 × 10–3 | 2.17 (1.05–4.86) | 0.05 |
KIM1 | 2.86 (1.89–4.53) | 2.6 × 10–6; 1.1 × 10–4 | 2.00 (1.21–3.49) | 9.4 × 10–3 | 2.46 (1.18–5.54) | 0.02 |
CSTB | 2.86 (1.88–4.62) | 4.8 × 10–6; 1.6 × 10–4 | 1.93 (1.17–3.35) | 0.01 | 2.08 (1.15–4.02) | 0.02 |
Gal-9 | 2.92 (2.01–4.44) | 9.2 × 10–8; 4.2 × 10–5 | 1.93 (1.20–3.19) | 7.6 × 10–3 | 7.97 (1.77–42.90) | 0.01 |
TIMP-1 | 2.41 (1.67–3.63) | 7.7 × 10–6; 2.1 × 10–4 | 1.85 (1.22–2.92) | 5.3 × 10–3 | 1.93 (1.13–3.45) | 0.02 |
MATN2 | 1.67 (1.22–2.33) | 1.8 × 10–3; 7.6 × 10–3 | 1.82 (1.21–2.83) | 5.4 × 10–3 | 2.51 (1.32–5.26) | 8.2 × 10–3 |
XCL1 | 1.74 (1.26–2.47) | 1.0 × 10–3; 5.3 × 10–3 | 1.72 (1.15–2.66) | 0.01 | 2.80 (1.23–7.61) | 0.03 |
NEMO | 1.47 (1.08–2.02) | 0.02; 0.04 | 1.71 (1.16–2.58) | 8.1 × 10–3 | 2.18 (1.29–3.93) | 5.5 × 10–3 |
CRELD2 | 1.82 (1.30–2.64) | 8.3 × 10–4; 4.5 × 10–3 | 1.68 (1.12–2.62) | 0.02 | 2.47 (1.45–4.55) | 1.7 × 10–3 |
MMP7 | 2.03 (1.46–2.92) | 5.4 × 10–5; 6.6 × 10–4 | 1.65 (1.09–2.54) | 0.02 | 3.25 (1.23–11.40) | 0.04 |
SUMF2 | 1.57 (1.15–2.18) | 0.01; 0.02 | 1.64 (1.12–2.46) | 0.01 | 2.89 (1.61–5.69) | 9.1 × 10–4 |
TXNDC5 | 1.72 (1.25–2.44) | 1.4 × 10–3; 0.01 | 1.58 (1.06–2.44) | 0.03 | 2.56 (1.52–4.60) | 7.5 × 10–4 |
PRELP | 1.92 (1.34–2.92) | 8.4 × 10–4; 4.5 × 10–3 | 1.56 (1.04–2.49) | 0.04 | 53.52 (4.47–961.00) | 3.5 × 10–3 |
TMSB10 | 1.70 (1.23–2.40) | 1.7 × 10–3; 7.5 × 10–3 | 1.56 (1.04–2.38) | 0.03 | 2.97 (1.65–6.03) | 8.4 × 10–4 |
CDH2 | 1.75 (1.28–2.47) | 8.2 × 10–4; 4.5 × 10–3 | 1.55 (1.04–2.37) | 0.04 | 2.00 (1.18–3.63) | 0.01 |
PARP-1 | 1.52 (1.11–2.15) | 0.01; 0.03 | 1.54 (1.07–2.31) | 0.03 | 2.59 (1.48–5.27) | 2.6 × 10–3 |
SPINT2 | 1.50 (1.11–2.08) | 0.01; 0.03 | 1.54 (1.04–2.31) | 0.03 | 2.09 (1.22–3.87) | 0.01 |
FCGR3B | 1.44 (1.06–1.99) | 0.02; 0.05 | 1.46 (1.01–2.16) | 0.05 | 1.84 (1.04–3.51) | 0.05 |
