Figure 1

Exposure to DSS promotes colon shortening, weight loss, and macroscopic damage in the colon, which is negatively correlated with reduced immobility time in the forced swim task. (a) Macroscopic damage score; Kruskal Wallis, Dunn’s post-test *p < 0.05 relative to control. Data shown are median ± 95% CI. (b) Colon length; One Way ANOVA, Dunnett’s post-test, *p < 0.05 relative to control. Data shown are mean ± SEM. (c) Change in body weight over course of DSS exposure; two-way ANOVA, Tukey’s post-test; *p < 0.05 versus control, #p < 0.05 versus 2%DSS treatment. Data shown are mean ± SEM. (d) Total immobility time in the forced swim task; One-way ANOVA, p = 0.0627. Data shown are mean ± SEM. (e) Immobility time as a function of macroscopic damage score; linear regression. N = 8 per group.