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Figure 1

From: Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

Figure 1

More astrocytes in the postnatal cerebral cortex of Dyrk1a+/− mice. (a) Schematic representation of a coronal brain section indicating the corpus callosum in grey and the region of the cerebral cortex (CX) for cell quantification. (b, d) Representative brain images from P5 (b) and P7 (d) Dyrk1a+/+ (+/+) and Dyrk1a+/− (+/−) mice stained for GFAP, indicating the position of the external (V-II) and internal (VI) cortical layers. The boxed areas are magnified to show GFAP+ astrocytes. Dotted lines define the white matter (WM). (c, e) Mean number (± SEM) of GFAP+ astrocytes quantified at P5 (c) and P7 (e) in 1000 μm wide columns expanding layers II to VI. The values correspond to individual animals obtained from 1 litter in c and from 2 litters in e: *P < 0.05 and ****P < 0.0001, Student’s t-test. Scale bars: 250 μm (b); 500 μm (d); 100 μm in magnifications.

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