Figure 5 | Scientific Reports

Figure 5

From: Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

Figure 5

The corpus callosum of adult Dyrk1a+/− mice is hypomyelinated. (a) Schematic representation of a sagittal brain section indicating the region of the corpus callosum (CC) analysed and representative images of the CC ultrastructure in 2-month-old (2 M) Dyrk1a+/+ (+/+) and Dyrk1a+/− (+ /−) mice. Scale bar: 1 μm. (b) Median value of the diameter (± interquartile range) of myelinated axons from each genotype. (c) Scattered plot of the g-ratios of individual fibres relative to their respective axon diameter. Green dots correspond to +/+ axons and red crosses to +/- axons. The dashed line indicates the median axon diameter in +/+ mice and the numbers on both sides of this line the percentages of axons below (left) or above (right) this value for each genotype. (d) Median value of the g-ratio (± interquartile range) for each genotype. Values in b-d were obtained from 980 (+/+) and 2024 (+/−) axons: n = 7–8 animals each genotype (3 litters); ns = not significant; ***P < 0.001, Mann–Whitney U test.

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