Figure 7 | Scientific Reports

Figure 7

From: Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

Figure 7

Slow velocities of action potential propagation in the corpus callosum of Dyrk1a+/− mice in vivo. (a) Scheme of the electrophysiological recordings performed in 2- (2 M) and 12-month-old (12 M) Dyrk1a+/− (+/−) and control (+/+) mice, and representative recording of compound action potentials (CAPs) arising from myelinated (N1) and unmyelinated (N2) axons. (b, c) Conduction velocities (mean ± SEM) for myelinated (b) and unmyelinated (c) axons in animals of the indicated age and genotype. n = 8–12 animals per genotype at 2 months (4 litters) and n = 7–9 animals per genotype at 12 months (3 litters): ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001 and ****P < 0.00, two-way ANOVA and Fisher’s LSD post-hoc test.

Back to article page