Figure 7 | Scientific Reports

Figure 7

From: Identification of potential targets of cinnamon for treatment against Alzheimer’s disease-related GABAergic synaptic dysfunction using network pharmacology

Figure 7

Computational procedure for prioritization of targets through network pharmacology. The pipeline for calculating target prioritization composes of 3 symbiotic blocks. The blue block searches metabolites from the Human Metabolome Database (HMDB) that interact with the GBRG2 protein, collates the metabolites, obtains the targets that interact with them, and screens them against drug availability in the Therapeutic Target Database (TTD). The grey module uses the STRING database to extract PPI from the proteins generated by the blue module and constructs a network from them. The green module uses molecular function (MF) annotations to calculate a GO-based semantic similarity score for the export of the blue module compared to GBRG2, ranking the proteins according to their similarity scores. The output of the green module was used to annotate the top 15 proteins in the network.

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