Figure 8 | Scientific Reports

Figure 8

From: Identification of potential targets of cinnamon for treatment against Alzheimer’s disease-related GABAergic synaptic dysfunction using network pharmacology

Figure 8

Integrated GBRG2-expanded multilayer biomolecular interaction network for candidate extraction and semantic similarity ranking of the proteins involved. (A) The complete network constructed using the major protein GBRG2 (orange nodes), linked to its direct metabolites (red nodes) which are linked to the proteins they interact with (blue nodes). We also show the metabolite-protein interactions (grey edges). (B) Semantic similarity ranking of proteins based on molecular function (MF SemSim) is highlighted, with the first 15 similar proteins. (C) The simplified network has only the main protein, with the top 12 similar proteins and metabolites shown separately, while the remaining proteins are grouped into modules and their interactions are merged.

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