Figure 8

Influence of MK-4 and MKH derivatives on cell death induced by complex-II, III, V, and depolarization mitochondrial inhibitors. The NIH/3T3 cells were treated with 0.03‒3 µM MK-4, MKH-DMG, or MKH-SUC for 24 h in the presence of (a) 2.5 mM 3-NP, (b) 30 µM AA, (c) 20 µM OA, and (d) 10 µM CCCP. Cell viability was determined using CTB assay. ***p < 0.001 versus vehicle group; ^###p < 0.001 versus 3-NP only group or CCCP only group; no significant (N.S.) versus AA only group or OA only group (Tukey’s test). Data are presented as mean ± SD (n = 3).