Figure 4 | Scientific Reports

Figure 4

From: Transcriptome profiling of colorectal tumors from patients with sepsis reveals an ethnic basis for viral infection risk and sepsis progression

Figure 4

Differentially expressed genes between Native Hawaiians and Japanese reveal Late Response Sepsis (LRS) genes involved in cell–cell junction regulation and barrier permeability. (a) Differentially expressed network indicating the connections and interacting partners of permeability-regulating junction canonical pathways (tight junction signaling, leukocyte extravasation signaling, remodeling of epithelial adherens junctions, FAK signaling, and integrin signaling). (b) Schematic of sepsis progression steps with listed potential biomarkers and associated ERS and LRS genes grouped by their predicted upstream regulators and affected pathways.

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