Figure 1 | Scientific Reports

Figure 1

From: Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases

Figure 1

Variance in eGenes explained by lead e-QLT variants. (A) Variance in eGenes explained by lead cis-eQTLs in relation to the distance in mega base pairs of the lead cis-eQTLs to the transcription start site (TSS) of the cis-gene. (B) Comparison of median variance in the expression levels of eGenes explained by the lead eQTL variants. The median value of variance explained in cis-eGenes was significantly higher than that of trans-eGenes (4.8% versus 2.8%, p < 2e−16). For cis-eGenes, the protein-coding-eGenes had slightly higher median variance explained in the expression level than cis-lncRNA genes (5.1% versus 4.3%, p = 0.0004). No significant difference in variance explained in trans-eGenes of protein-coding genes versus trans-lncRNA genes (2.8% versus 2.7%, p = 0.41).

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