Table 1 Top 25 cis-eQTLs (p < 5e−8).

From: Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases

Gene Symbol	SNP	Chr	SNP position	Gene start position	R²	Beta	log10P	OA	EA	EAF	Type
PPIE	rs7513045	1	39,738,494	39,692,182	0.84	11.40	− 1029.25	G	T	0.36	protein_coding
CCDC163	rs4660860	1	45,480,561	45,493,866	0.90	− 3.10	− 1286.89	T	A	0.30	protein_coding
CYP26B1	rs13430651	2	72,215,195	72,129,238	0.81	1.98	− 920.005	G	A	0.15	protein_coding
MAP3K2-DT	rs2276683	2	127,389,186	127,389,130	0.88	− 1.61	− 1176.37	G	C	0.23	lincRNA
SLC12A7	rs35188965	5	1,104,823	1,050,384	0.81	− 29.87	− 915.459	C	T	0.44	protein_coding
ENC1	rs112772452	5	74,631,048	74,627,406	0.83	14.53	− 986.798	CA	C	0.11	protein_coding
ERAP2	rs2910686	5	96,916,885	96,875,939	0.85	36.98	− 1044.91	T	C	0.43	protein_coding
BTNL3	rs72494581	5	181,003,797	180,988,845	0.82	13.52	− 950.405	T	C	0.30	protein_coding
HLA-DRB5	rs68176300	6	32,558,713	32,517,353	0.83	− 178.13	− 1003.76	T	G	0.15	protein_coding
AL512625.3	rs1845054	9	62,906,092	62,856,999	0.83	− 1.19	− 993.655	T	C	0.13	lincRNA
CUTALP	rs13299616	9	120,832,525	120,824,828	0.86	− 23.25	− 1092.88	T	C	0.40	transcribed_unitary_pseudogene
LDHC	rs201993031	11	18,412,985	18,412,318	0.82	0.16	− 946.833	CCCTTCCTT	C	0.12	protein_coding
ACCS	rs2074038	11	44,066,439	44,065,925	0.83	16.69	− 997.26	G	T	0.11	protein_coding
FADS2	rs968567	11	61,828,092	61,792,980	0.88	31.41	− 1186.37	C	T	0.17	protein_coding
XRRA1	rs10899051	11	74,931,506	74,807,739	0.91	5.38	− 1327.88	G	A	0.26	protein_coding
B4GALNT3	rs1056008	12	553,672	460,364	0.85	6.71	− 1043.34	T	C	0.25	protein_coding
DDX11	rs3891006	12	31,073,506	31,073,860	0.86	− 13.25	− 1102.08	A	G	0.44	protein_coding
RPS26	rs1131017	12	56,042,145	56,041,351	0.81	− 134.34	− 929.902	C	G	0.39	protein_coding
C17orf97	rs7503725	17	410,351	410,325	0.85	1.89	− 1055.68	G	T	0.25	protein_coding
AC126544.2	rs2696531	17	46,278,268	45,586,452	0.86	1.04	− 1097.79	C	A	0.21	lincRNA
SPATA20	rs9890200	17	50,547,162	50,543,058	0.81	− 1.01	− 34.173	A	C	0.37	protein_coding
CEACAMP3	rs3745936	19	41,586,462	41,599,735	0.84	1.11	− 040.05	A	T	0.22	transcribed_unprocessed_pseudogene
PWP2	rs2277806	21	44,089,769	44,107,373	0.87	3.16	− 139.85	A	C	0.19	protein_coding
GATD3A	rs3788104	21	44,092,213	44,133,610	0.86	4.25	− 104.35	G	A	0.18	protein_coding
FAM118A	rs576259663	22	45,363,712	45,308,968	0.86	43.45	− 1108.47	T	TA	0.12	protein_coding

EA effect allele, OA the other allele, EAF effect allele frequency; R² variance explained by the lead eQTL (SNP).

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Table 1 Top 25 cis-eQTLs (p < 5e−8).

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