Table 2 Comparison of effect sizes of eQTLs with different minor allele frequency ranges.

From: Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases

MAF range

n

Median effect size

1st Quartile effect size

3rd Quartile effect size

Cis-eQTL variants

[0.1, 0.5)

1,960,534

0.44

0.12

1.41

[0.05, 0.1)

390,362

0.64

0.17

2.02

[0.01, 0.05)

424,024

0.98

0.29

2.84

(0.003–0.01)

80,191

1.77

0.50

5.03

Trans-eQTL variants

[0.1, 0.5)

321,275

0.42

0.12

1.01

[0.05, 0.1)

81,083

0.69

0.17

1.36

[0.01, 0.05)

94,234

0.89

0.38

1.71

(0.003–0.01)

29,464

2.38

0.80

8.13

  1. MAF minor allele frequency, n the number of eQTLs, effect size the effect size of association between eQTL and eGene.
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