Table 2 The top 10 most significant SNPs.
From: A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Chr | SNP | Position | Alleles | LR | P-value* | \({\beta }^{**}\) | P-value** | \({\beta }^{***}\) | P-value*** | \({\beta }^{****}\) | P-value**** | Gene |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
5 | rs2961757 | 151,936,718 | T/G | 38.88 | 3.61 × 10−9 | − 0.18 | 0.01 | 0.26 | \(1.18\times {10}^{-7}\) | 0.44 | 3.41 × 10−8 | NMUR2, LINC01470 |
18 | rs9303897 | 2,306,842 | G/A | 32.29 | 9.74 × 10−8 | 0.36 | 8.11 × 10−8 | − 0.06 | 0.23 | − 0.42 | 7.19 × 10−8 | LINC00470, METTL4 |
6 | rs1770 | 32,627,833 | G/A | 31.21 | 1.67 × 10−7 | − 0.03 | 0.67 | 0.31 | \(3.74\times {10}^{-8}\) | 0.34 | 7.14 × 10−5 | HLA-DQB1-AS1 |
6 | rs10947233 | 32,124,424 | T/G | 29.13 | 4.74 × 10−7 | − 0.47 | \(1.16\times {10}^{-7}\) | − 0.03 | 0.65 | 0.45 | 3.27 × 10−6 | PPT2-EGFL8 |
17 | rs146362423 | 21,488,273 | C/G | 27.58 | 1.03 × 10−6 | − 0.53 | \(1.3\times {10}^{-6}\) | 0.07 | 0.36 | 0.60 | 1.12 × 10−6 | C17orf51, UBBP4 |
7 | rs1568778 | 109,250,932 | T/C | 27.20 | 1.24 × 10−6 | 0.08 | 0.21 | − 0.24 | \(1.83\times {10}^{-6}\) | − 0.32 | 2.14 × 10−5 | C7orf66, EIF3IP1 |
7 | rs115881004 | 68,928,894 | T/C | 27.08 | 1.32 × 10−6 | 0.35 | \(5.29\times {10}^{-5}\) | − 0.19 | 0.01 | − 0.54 | 1.77 × 10−7 | LOC102723427, LOC100507468 |
6 | rs114968045 | 32,666,960 | C/T | 25.76 | 2.54 × 10−6 | − 0.19 | 0.02 | 0.24 | \(3.35\times {10}^{-5}\) | 0.43 | 8.59 × 10−7 | HLA-DQB1, HLA-DQA2 |
14 | rs11623972 | 73,381,520 | G/A | 25.45 | 2.98 × 10−6 | − 0.32 | \(6.45\times {10}^{-7}\) | − 0.05 | 0.27 | 0.27 | 2.81 × 10−4 | DPF3, DCAF4 |
9 | rs10758715 | 5,882,401 | C/T | 24.75 | 4.22 × 10−6 | − 0.11 | 0.11 | − 0.25 | \(1.51\times {10}^{-6}\) | − 0.14 | 7.33 × 10−2 | ERMP1, MLANA |
