Figure 4 | Scientific Reports

Figure 4

From: Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory

Figure 4

Association of SARS-CoV-2 mRNA vaccine-induced early CD4+ T cell responses and B cell memory. (a) The correlation between the frequencies of S1-reactive AIM+ CD4+ T cells at 1 week after the 2nd dose of the BNT162b2 mRNA vaccine (T1) and serum SARS-CoV-2 IgG levels at 2 months after the 3rd vaccine dose (B-T2) is shown. (b) Correlations of the frequency of SARS-CoV-2 spike RBD-specific IgG+ memory B cells at B-T2 with the frequencies of S1-reactive AIM+ CD4+ T cells, cTfh cells and cTph cells at T1 are shown. Each dot indicates the value for one individual. Correlations were analyzed using Spearman’s correlation analysis. *P < 0.05, **P < 0.01.

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