Figure 1
From: Quantitative tissue perfusion imaging using nonlinear ultrasound localization microscopy
Ultrasound localization microscopy (ULM) improves image resolution compared to contrast-enhanced Doppler imaging. Representative longitudinal images of thoracic levels 8 and 9 of the rat spinal cord are depicted. (a) Plots of the normalized amplitude across a subset of vessels (b,c, dashed yellow line) are shown. (c) ULM produces significantly smaller vessel profiles compared to (b) contrast-enhanced Doppler imaging (36.1±6.77 um vs. 120±11.2 um, respectively), and distinguishes two separate vessels that overlap in the Doppler image (red ellipse in a). Matched zoomed regions illustrate the improved image fidelity in the ULM case (d,e). Doppler images are displayed with 20 dB dynamic range; ULM density maps are scaled from 0 to 30 detected bubbles.
