Figure 2
From: Quantitative tissue perfusion imaging using nonlinear ultrasound localization microscopy
Nonlinear imaging improves sensitivity and resolution compared to conventional ULM. (a,b) Representative ULM images of thoracic levels 7–8 are displayed. ULM processing was conducted on the same acquisitions, using either the linear (a; i.e., all pulses summed) or nonlinear (b; i.e., half pulses subtracted for linear signal cancellation) signal components. Green arrows indicate regions with improved sensitivity; this is particularly pronounced in the ventral aspect of the spinal cord. (c–f) Zoomed images depict representative regions (blue boxes) wherein nonlinear ULM better resolved small vessels (FWHM: 35.0 ± 5.69 um vs. 46.0 ± 8.89 um in c–f; vessels selected for measurement are marked).
