Figure 6
From: Quantitative tissue perfusion imaging using nonlinear ultrasound localization microscopy
Nonlinear ULM enables novel quantitative analysis and display methods. Perfusion ULM images are depicted at baseline (a,b) and post unilateral contusion injury (c,d). Density maps (top) are displayed above quantitative parametric maps (bottom). These parametric maps show the average in-plane travel distance within each bin (in um). These maps recapitulate inherent biological contrast between the gray and white matter at baseline (b) and describe pathological disruption of flow in the penumbra following injury (d). This agreed with histological analysis (e,f), which similarly indicated a reduced microvessel density (anti-laminin in green; 504 vs. 283 vessels/mm\(^2\)) and mean vessel length between the contralateral gray matter and injury penumbra (19.8 ± 1.12 vs 16.5 ± 1.51 um). The corresponding penumbra (dashed yellow) and contralateral gray matter (dashed red) regions are displayed on the ULM image in panel (c).
