Table 3 Cox regression analysis of the factors for cumulative risk of surgical resection in patients with moderate to severe UC exacerbations.

From: The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort

Variables

Univariate analysis

P

Multivariate analysis

P

Hazard ratio

95% CI

Hazard ratio

95% CI

Age, ≥ 60 years

1.895

1.133–3.170

0.015

2.269

1.341–3.840

0.002

First attack

0.825

0.436–1.560

0.554

0.997

0.511–1.945

0.993

Pancolitis UC

1.432

0.924–2.221

0.108

1.156

0.737–1.813

0.528

Severe exacerbation

3.954

2.545–6.142

 < 0.001

2.973

1.860–4.754

 < 0.001

History of COR-REF or DEP

3.986

2.576–6.167

 < 0.001

2.920

1.806–4.720

 < 0.001

Corticosteroids

0.569

0.368–0.879

0.011

0.666

0.419–1.057

0.085

Apheresis

2.021

1.302–3.136

0.002

1.807

1.132–2.884

0.013

Calcineurin inhibitors

5.059

3.246–7.884

 < 0.001

2.695

1.657–4.383

 < 0.001

Biologics

1.355

0.849–2.164

0.203

0.913

0.556–1.499

0.719

Back to article page