Table 4 Cox regression analysis of the factors for cumulative risk of re-exacerbation in patients with moderate to severe UC exacerbations.

From: The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort

Variables

Univariate analysis

P

Multivariate analysis

P

Hazard ratio

95% CI

Hazard ratio

95% CI

Age, ≥ 60 years

0.828

0.611–1.115

0.214

0.813

0.603–1.096

0.174

First attack

0.976

0.771–1.236

0.839

0.803

0.612–1.054

0.113

Pancolitis UC

1.227

1.015–1.484

0.035

1.217

1.065–1.391

0.004

Severe exacerbation

1.238

1.000–1.533

0.050

1.133

0.902–1.424

0.283

History of COR-REF or DEP

0.846

0.664–1.077

0.173

0.930

0.716–1.209

0.589

5-ASA

1.046

0.859–1.274

0.652

1.161

0.911–1.480

0.226

Corticosteroids

1.436

1.164–1.772

0.001

1.473

1.183–1.833

0.001

Apheresis

0.992

0.803–1.226

0.944

0.977

0.785–1.216

0.837

Calcineurin inhibitors

1.115

0.886–1.404

0.353

1.206

0.939–1.549

0.142

Immunomodulators

1.051

0.754–1.467

0.768

1.066

0.760–1.480

0.712

Biologics

0.527

0.389–0.713

 < 0.001

0.501

0.367–0.683

 < 0.001

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