Figure 2

Receiver operating characteristic (ROC) curve analysis of biomarkers for triage and TB treatment. ROC curves for comparing the performance of different markers between healthy donors (HD) and TB infected (TBI) (A), active TB infection (ATB) vs. TBI (B), HD vs. ATB (C), and finally Fast and Slow treatment responders, are shown. In the top left box, the solid and dashed lines represent the respective optimal and minimum criteria set by the WHO in the target product profile (TPP) for a triage test for TB.