Table 1 Summarised characteristics of reviewed studies.

From: Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis

Total

25 studies

Year of publication

1995–2020

Total patients (range)

3326 (22–420)

Sequencing technique

Sanger

17

Next-generation

7

Pyrosequencing

1

Anatomical subsite

Mixed

9 studies (1957 patients)

Oral

8 studies (994 patients)

Larynx

5 studies (238 patients)

Oropharynx

1 study (68 patients)

Sinonasal

1 study (57 patients)

Nasopharyngeal

1 study (22 patients)

Outcome measures

Overall survival

21 studies

Disease free survival

14 studies

Disease specific survival

3 studies

Geographical region

Europe

12 studies, 7 countries: Italy, Netherlands, Serbia, Germany, Denmark, Sweden, France

North America

6 studies, 2 countries: USA, Canada

Asia

6 studies, 3 countries: Japan, China, Taiwan

Oceania

1 study, 1 country: Australia