Figure 6
From: Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
Cancer-derived mutation mapping in CCR5 structure. (a) The mutations found in the GDC dataset for CCR5 mapped on the 3D structure of the receptor. (b) Mutated residues found in ECL2 region. (c) G protein binding site, containing the mutation A2336.33E, which has been characterized as a thermostabilizing mutation for the inactive CCR5 structure (PDB code 4MBS). (d) The orthosteric binding site, with the small molecule inhibitor maraviroc (orange).
