Table 3 Distribution of acute and late RT-induced GU or GI toxicity between patients with genotypes of TGFB1 C-509T, TGFB1 Leu10Pro and XRCC3 Thr241Met.

From: Association of polymorphisms in TGFB1, XRCC1, XRCC3 genes and CD8 T-lymphocyte apoptosis with adverse effect of radiotherapy for prostate cancer

 

TGFB1 C-509T

TGFB1 Leu10Pro

XRCC3 Thr241Met

Acute

GU toxicity

CC: 97.8%

CT: 86.7%

TT: 100%

LeuLeu: 100%

LeuPro: 90.7%

ProPro: 100%

ThrThr: 100%

ThrMet: 94.6%

MetMet: 81.8%

Acute

GU toxicity

(grade 1 vs. Grade 2 plus 3)

Grade 1:

CC: 70.5%

CT: 61.5%

TT: 54.5%

Grade 2 plus 3:

CC: 29.5%

CT: 38.5%

TT: 45.5%

Grade 1:

LeuLeu: 76.0%

LeuPro: 59.0%

ProPro: 64.3%

Grade 2 plus 3:

LeuLeu: 24.0%

LeuPro: 41%

ProPro: 35.7%

Grade 1:

ThrThr: 54.5%

ThrMet: 71.4%

MetMet: 77.8%

Grade 2 plus 3:

ThrThr: 45.5%

ThrMet: 28.6%

MetMet: 22.2%

Acute

GI toxicity

CC: 95.6%

CT: 83.3%

TT: 100%

LeuLeu: 92.0%

LeuPro: 88.4%

ProPro: 100%

ThrThr: 90.9%

ThrMet: 91.9%

MetMet: 90.9%

Acute

GI toxicity

(grade 1 vs. Grade 2 plus 3)

Grade 1:

CC: 76.7%

CT: 68%

TT: 81.8%

Grade 2:

CC: 23.3%

CT: 32%

TT: 18.2%

Grade 1:

LeuLeu: 78.3%

LeuPro: 73.7%

ProPro: 78.6%

Grade 2:

LeuLeu: 21.7%

LeuPro: 26.3%

ProPro: 21.4%

Grade 1:

ThrThr: 76.7%

ThrMet: 76.5%

MetMet: 60%

Grade 2:

ThrThr: 23.3%

ThrMet: 23.5%

MetMet: 40%

Late

GU toxicity

Yes:

CC: 71.1%

CT: 70.0%

TT: 63.6%

Yes:

LeuLeu: 72.0%

LeuPro: 72.1%

ProPro: 64.3%

Yes:

ThrThr: 78.8%

ThrMet: 64.9%

MetMet: 63.6%

Late

GU toxicity

(grade 1 vs. Grade 2 plus 3)

Grade 1:

CC: 71.9%

CT: 47.6%

TT: 71.4%

Grade 2 plus 3:

CC: 28.1%

CT: 52.4%

TT: 28.6%

Grade 1:

LeuLeu: 72.2%

LeuPro: 58.1%

ProPro: 66.7%

Grade 2 plus 3:

LeuLeu: 27,8%

LeuPro: 41.9%

ProPro: 33.3%

Grade 1:

ThrThr: 61.5%

ThrMet: 70.8%

MetMet: 42.9%

Grade 2 plus 3:

ThrThr: 38.5%

ThrMet: 29.1%

MetMet: 57.1%

Late

GI toxicity

Yes:

CC: 28.9%

CT: 23.3%

TT: 36.4%

Yes:

LeuLeu: 28.0%

LeuPro: 27.9%

ProPro: 28.6%

Yes:

ThrThr: 24.2%

ThrMet: 32.4%

MetMet: 18.2%

Late

GI toxicity

(grade 1 vs. Grade 2 plus 3)

Grade 1:

CC: 76.9%

CT: 100%

TT: 75.0%

Grade 2:

CC: 23.1%

CT: 0%

TT: 25.0%

Grade 1:

LeuLeu: 71.4%

LeuPro: 91.7%

ProPro: 75.0%

Grade 2:

LeuLeu: 28.6%

LeuPro: 8.3%

ProPro: 25.0%

Grade 1:

ThrThr: 62.5%

ThrMet: 91.7%

MetMet: 100%

Grade 2:

ThrThr: 37.5%

ThrMet: 8.3%

MetMet: 0%

  1. GU- genitourinary; GI- gastrointestinal.
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