Table 6 Prediction of late GU and GI radiotoxicity.

From: Association of polymorphisms in TGFB1, XRCC1, XRCC3 genes and CD8 T-lymphocyte apoptosis with adverse effect of radiotherapy for prostate cancer

Variable

Occurrence of late GU toxicity

Occurrence of late GI toxicity

p value

OR (95% CI)

p value

OR (95% CI)

Age

0.385

1.031 (0.962–1.106)

0.299

1.041 (0.965–1.122)

Initial PSA value

0.610

1.011 (0.970–1.053)

0.076

1.035 (0.996–1.076)

Diabetes mellitus type 2

0.869

1.104 (0.342–3.567)

0.001

0.145 (0.045–0.466)

Smoking status

0.871

0.920 (0.340–2.495)

0.634

1.278 (0.466–3.503)

Chronic hypertension

0.983

1.011 (0.394–2.589)

0.721

1.190 (0.457–3.098)

Type of radiotherapy

0.716

0.843 (0.335–2.117)

0.511

0.724 (0.277–1.895)

Gleason score

0.030

2.440 (1.092–5.449)

0.663

1.158 (0.598–2.244)

Risk group

0.037

2.256 (1.052–4.837)

0.303

1.497 (0.695–3.227)

RILA value

0.073

1.045 (0.996–1.096)

0.118

1.033 (0.992–1.075)

TGFB1 C-509T genotypes

0.670

0.869 (0.455–1.659)

0.867

1.058 (0.544–2.060)

TGFB1 Leu10Pro genotypes

0.662

1.170 (0.579–2.362)

0.975

0.989 (0.485–2.015)

XRCC3 Thr241Met genotypes

0.215

0.644 (0.321–1.292)

0.993

0.997 (0.488–2.037)

  1. Bolded values indicate statistically significant data or statistical trend.
  2. GU- genitourinary; GI- gastrointestinal.