Figure 8 | Scientific Reports

Figure 8

From: Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

Figure 8

Schematic diagram demonstrating a possible mechanism of compound 4 on the modulation of SRD5A1 in human keratinocyte cells. Compound 4 mediates the lower level of DHT production together with down-regulating of SRD5A1 protein expression, which possibly involves the mixed-mode inhibition.

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