Figure 5 | Scientific Reports

Figure 5

From: Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer

Figure 5

Serum N-glycan differences between benign (n = 45) and cancer (n = 11) samples from patients aged 50–74 and with a BMI of 18.5–24.9. Log-transformed relative intensity values of the (a) 1850.666 m/z (A2BG1F1) and (b) 2163.743 m/z (A2BG1F1S1) N-glycans and (c) bisecting N-glycan class had significant differences in benign and cancer samples using a 5% false discovery rate. (d) Using the log-transformed relative intensities of the two individual N-glycans, age, and BMI, benign and cancer samples could be distinguished with an AUROC of 0.899, sensitivity of 82%, and specificity of 84%. N-glycan compositions are represented by blue squares for N-acetylglucosamine, green circles for mannose, yellow circles for galactose, purple diamonds for sialic acid, and red triangles for fucose.

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