Figure 6
From: Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle
PD-L1 glycosylation differences associated with compound treatments. (A) WB signal for FLAG-PD-L1 in HEK293 T cells overexpression system. A high molecular weight glycosylation species is absent from PD-L1 samples treated with dimer-inducing compounds (arrows). (B) Dimerized PD-L1 is more susceptible to EndoH than monomeric PD-L1 (arrows indicate the EndoH-resistant species).
