Figure 6
Molecular interactions of DRP1i27 at the active site of Drp1. (A) Chemical structure and physicochemical properties of DRP1i27. (B) Representative image of DRP1i27 in the active site of human Drp1 protein. Protein surface was coloured according to electrostatic potential of surface residues. Dark red, negative charge; Dark blue, positive charge. White, neutral charge. (C) 3D representation of hydrogen bonding interactions and (D) 2D representation of hydrophobic interactions of DRP1i27 at the active site. For clarity, non-polar hydrogen atoms are hidden from view. Secondary structure of the active site is depicted as light grey cartoon. Yellow dashed lines indicate hydrogen bonds. Blue, nitrogen atom; Red, oxygen atom. Lime green and gray stick backbones, carbon atom. Interactions were predicted using PyMOL v2.5.2 and LigPlot v1.4.5.
