Table 2 Risk factor of overall survival in advanced major salivary gland cancer patients, n = 395.

From: No survival benefit from adding chemotherapy to adjuvant radiation in advanced major salivary gland cancer

 

Crude HR (95% C.I.)

P-value

Adjusted HR (95% C.I.)

P-value

CRT vs RT

0.90 (0.72–1.14)

0.3771

0.94 (0.72–1.23)

0.6654

Age

< 65

Ref.

 

Ref.

 

65

1.33 (1.01–1.75)

0.0434

1.36 (1.01–1.83)

0.0410

Gender

Male

0.98 (0.78–1.23)

0.8538

0.99 (0.78–1.26)

0.9320

Female

Ref.

 

Ref.

 

Grade

Well/moderately

Ref.

 

Ref.

 

Poorly/undifferentiated

1.15 (0.89–1.48)

0.2912

1.14 (0.87–1.50)

0.3296

Primary site criteria

Parotid gland

Ref.

 

Ref.

 

Submandibular gland

0.97 (0.74–1.27)

0.8388

1.02 (0.76–1.36)

0.9152

Sublingual gland

1.19 (0.73–1.96)

0.4830

1.38 (0.80–2.38)

0.2511

Overlapping lesion of major salivary glands and major salivary gland, NOS

1.02 (0.42–2.49)

0.9578

1.01 (0.40–2.52)

0.9850

Histological types

Adenoid cystic carcinoma

0.87 (0.66–1.14)

0.3013

0.79 (0.58–1.10)

0.1622

Others

Ref.

 

Ref.

 

pT classification

1–2

Ref.

 

Ref.

 

3–4

1.05 (0.78–1.41)

0.7723

0.95 (0.66–1.36)

0.7653

pN classification

0

Ref.

 

Ref.

 

1–3

0.90 (0.72–1.13)

0.3565

0.84 (0.63–1.11)

0.2204

Margin

Positive

0.89 (0.70–1.13)

0.3508

0.91 (0.70–1.18)

0.4668

Negative

Ref.

 

Ref.

 

CCI

0

Ref.

 

Ref.

 

1

0.78 (0.56–1.09)

0.1493

0.77 (0.54–1.08)

0.1308

2

0.89 (0.66–1.20)

0.4353

0.84 (0.62–1.14)

0.2635

  1. RT radiotherapy, CRT chemoradiotherapy, CCI Charlson Comorbidity Index.