Table 7 The first 15 proteins with the most significant change in intensity (according to M versus S) from the intersection of M versus any other group comparisons.
From: Acute and chronic blood serum proteome changes in patients with methanol poisoning
Protein | Increase or decrease in intensity for M | Category of function | Significant change |
|---|---|---|---|
ITIH4_HUMAN Inter-alpha-trypsin inhibitor heavy chain H4 (Uniprot id = Q14624)* | ↓ | Inflammation processes, Blood coagulation cascade, Plasminogen cascade | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
B7ZKJ8_HUMAN Inter-alpha-trypsin inhibitor heavy chain H4 (other isoform, Uniprot id = B7ZKJ8)** | ↓ | Inflammation processes, Blood coagulation cascade, Plasminogen cascade | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
KNG1_HUMAN Kininogen-1 (UniProt id = P01042)*** | ↓ | Blood coagulation cascade | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
IPSP_HUMAN Plasma serine protease inhibitor | ↓ | Plasminogen cascade | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
CO3_HUMAN Complement C3 | ↑ | Inflammation processes | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
CBPQ_HUMAN Carboxypeptidase Q | ↓ | Blood coagulation | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
COL11_HUMAN collectin-11 | ↑ | Immune system | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
ANGI_HUMAN Angiogenin | ↓ | Induces vascularization | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
D6RAQ1_HUMAN Heparanase isoform 3 of heparanase | ↓ | Regulates cell proliferation and angiogenesis | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
PLMN_HUMAN Plasminogen | ↓ | Anticoagulant, Inflammation processes | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
KNG1_HUMAN Kininogen-1 (other isoforms, UniProt id = P01042-2, P02042-3)**** | ↓ | Blood pressure regulation | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
GELS_HUMAN Gelsolin | ↓ | Regulates the architecture and dynamics of cells | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
FETUA_HUMAN Alpha-2-HS-glycoprotein | ↓ | Endocytosis | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
FGD6_HUMAN Isoform 2 of FYVE, RhoGEF and PH domain-containing protein 6 | ↓ | JNK pathway | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
E7ES19_HUMAN Thrombospondin-4 | ↓ | Blood coagulation | (M versus S) ∩ (M versus C) ∩ (M versus SC) |
TITIN_HUMAN Titin | ↓ | Inflammation processes | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
FGFR1_HUMAN Fibroblast growth factor receptor 1 | ↓ | Cell proliferation and differentiation | Mpair versus Spair |
SRGN_HUMAN Serglycin | ↓ | Cell apoptosis | Mpair versus Spair |
HYES_HUMAN Bifunctional epoxide hydrolase 2 | ↓ | Inflammation processes | Mpair versus Spair |
APOH_HUMAN Beta-2-glycoprotein 1 | ↓ | Complement and coagulation cascade | Mpair versus Spair |
SEM4B_HUMAN Semaphorin-4B | ↑ | Synaptogenesis | (M versus S) ∩ (M versus C) ∩ (M versus SC), Mpair versus Spair |
