Table 1 In vitro cytotoxicity (IC50) of compounds (DD-01 to DD-19) and effective treatment dose (EC50) of selected compounds (having IC50 greater than that of the reference compound BP).

From: Probing photoprotection properties of lipophilic chain conjugated thiourea-aryl group molecules to attenuate ultraviolet-A induced cellular and DNA damages

Compounds

Cytotoxic dose

IC50 (µM ± SEMb)

Effective treatment dose

EC50 (µM ± SEMb)

BPa

53.4 ± 1.12

3.692 ± 1.15

DD-01

46.95 ± 1.08

 

DD-02

60.86 ± 1.21

5.541 ± 1.2

DD-03

60.39 ± 1.05

4.958 ± 1.2

DD-04

63.42 ± 1.04

4.876 ± 1.17

DD-05

48.34 ± 1.05

 

DD-06

32.65 ± 1.14

 

DD-07

75.35 ± 1.12

7.437 ± 1.2

DD-08

47.6 ± 1.09

 

DD-09

81.45 ± 1.19

6.761 ± 1.2

DD-10

51.78 ± 1.05

 

DD-11

62.99 ± 1.18

11.33 ± 1.06

DD-12

34.91 ± 1.12

 

DD-13

48.03 ± 1.06

 

DD-14

54.14 ± 1.04

4.497 ± 1.15

DD-15

81.98 ± 1.18

6.218 ± 1.19

DD-16

33.37 ± 1.12

 

DD-17

43.89 ± 1.08

 

DD-18

66.35 ± 1.08

21.54 ± 1.2

DD-19

28.59 ± 1.31

 
  1. aBP is the reference UV filter benzophenone. bSEM is the standard error of the mean. All data were represented as mean ± standard error of the mean. Experiments were performed in triplicates (n = 3). For IC50 evaluation, the highest concentration was 100 µM and the IC50 concentration of each of the selected compounds was taken as the highest concentration for estimation of EC50. IC50 and EC50 values were calculated using Graph pad prism 6 software which was obtained using four concentrations of reference and test compounds.
Back to article page