Table 1 Top chemicals correlated with up and down signatures in the connectivity map by using DEGs.

CMap name	Mean	n	Enrichment	p	Specificity	Percent non-null
Thiamine	− 0.727	3	− 0.96	0.00018	0	100
SC-560	− 0.58	3	− 0.899	0.00194	0.0121	100
Hycanthone	− 0.312	4	− 0.803	0.00294	0.0168	50
Biperiden	− 0.355	5	− 0.723	0.00348	0.1088	60
Myosmine	− 0.38	6	− 0.665	0.00399	0.0111	83
Pirenperone	− 0.415	5	− 0.711	0.00433	0	80
MK-886	− 0.716	2	− 0.936	0.00861	0	100
Bacitracin	− 0.582	3	− 0.837	0.00861	0.0242	100
Vinburnine	− 0.413	4	− 0.742	0.00871	0	75
Prestwick-983	− 0.621	3	− 0.834	0.00915	0.0206	100
Iohexol	− 0.416	4	− 0.724	0.0118	0.0511	75
Chloropyrazine	− 0.515	4	− 0.723	0.012	0.0195	75
Betazole	− 0.424	5	− 0.628	0.01846	0.007	80
Rilmenidine	− 0.393	4	− 0.694	0.01866	0.0274	75
Fenofibrate	− 0.412	3	− 0.789	0.01913	0.0581	66
Eticlopride	− 0.282	4	− 0.69	0.02003	0.0379	50
Oxolamine	− 0.222	4	− 0.689	0.02029	0.0461	50
Lisuride	− 0.258	5	− 0.614	0.02363	0.2869	60
Prestwick-857	− 0.341	4	− 0.673	0.02564	0.051	75
Chenodeoxycholic acid	− 0.444	4	− 0.673	0.02564	0.1308	75
Bretylium tosilate	− 0.3	4	− 0.671	0.02616	0.0385	50
Lovastatin	− 0.287	4	− 0.667	0.02765	0.0388	50
Quipazine	− 0.237	4	− 0.648	0.03648	0.0315	50
Clidinium bromide	− 0.491	4	− 0.638	0.04116	0.0245	75
Harmol	− 0.433	4	− 0.63	0.04603	0.1585	75

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