Figure 1
From: AS-CMC: a pan-cancer database of alternative splicing for molecular classification of cancer
AS-CMC workflow. AS-CMC provides three analysis modules. In the “Subtype-specific AS” module (top left), differential regulation of AS PSI values was tested among molecular subtypes provided by TCGAbiolinks. We used AS events in five splice types (ES, RI, AA, AD, and ME). In the “Phenotype association” module (bottom left), each AS event was evaluated in association with patient-level (clinical outcomes), tissue-level (microenvironment), and gene-level (gene-expression) data. In the “Pan-cancer comparison” module (right), the analyzed data pertaining to each AS event is displayed in a panoramic view across cancer types. In the pan-cancer view, users can access plots summarizing subtype-specificity, clinical implications, and correlations with gene expression. The figure was created with BioRender.com.
