Figure 2 | Scientific Reports

Figure 2

From: Acute toxicities of patients with locally advanced rectal cancer treated with intensified chemoradiotherapy within the CAO/ARO/AIO-12 trial: comparing conventional versus VMAT planning at a single center

Figure 2

(a) Dependence of diarrhea on irradiated small bowel volume of all evaluated patients (n = 34) treated with 3D-conformal radiotherapy. Dose levels V5-50 are displayed as boxplots; box = interquartile range, solid horizontal line = median, dotted horizontal line = mean, whiskers 1.5 × IQR, dots = outliers. Statistical analysis was performed using Wilcoxon rank-sum test. A p-value < 0.05 was considered statistically significant. * = significant difference p < 0.05, ccm = cubic centimeter. (b) Reduction of irradiated small bowel volume receiving doses from 5 to 50 Gy after volumetric modulated arc therapy (VMAT) re-planning compared to the 3D-conformal radiotherapy treatment plans. Mean dose levels V5–V50 are displayed. Statistical analysis was performed using Wilcoxon signed rank test. A p-value < 0.05 was considered statistically significant. * = significant difference p < 0.01, ccm = cubic centimeter, 3D-RT = 3D-conformal radiotherapy, VMAT = volumetric modulated arc therapy.

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