Table 3 Dose-volume parameters for 3D-RT and VMAT plans.

From: Acute toxicities of patients with locally advanced rectal cancer treated with intensified chemoradiotherapy within the CAO/ARO/AIO-12 trial: comparing conventional versus VMAT planning at a single center

 

Dmean (Gy)

Dmax (Gy)

V5 (ccm)

V10 (ccm)

V15 (ccm)

V20 (ccm)

V25 (ccm)

V30 (ccm)

V35 (ccm)

V40 (ccm)

V45 (ccm)

V50 (ccm)

Bladder (mean volume 288.2 ccm)

3D-RT

26.3

51.0

          

VMAT

21.9

51.7

          

p-value

 < 0.01

 < 0.01

          

Bladder wall (mean volume 111.1 ccm)

3D-RT

27.5

50.1

          

VMAT

24.5

51.7

          

p-value

 < 0.01

 < 0.01

          

Small bowel (mean volume 759.0 ccm)

3D-RT

11.3

49.0

522.3

344.0

128.9

86.9

74.3

63.5

52.0

42.9

34.1

10.6

VMAT

7.6

50.1

366.3

150.7

87.4

61.8

46.8

37.7

31.9

27.4

22.6

11.5

p-value

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

0.57

Sphincter (mean volume 15.5 ccm)

3D-RT

35.6

46.8

13.8

11.9

11.5

11.2

10.9

10.7

10.4

10.1

9.3

4.7

VMAT

34.6

46.3

13.6

11.9

11.3

11.1

10.7

10.3

10.0

9.4

8.8

4.8

p-value

 < 0.01

0.10

0.13

0.86

0.10

0.01

0.09

 < 0.01

 < 0.01

 < 0.01

 < 0.01

0.83

Femoral head right (mean volume 172.2 ccm)

3D-RT

25.9

46.6

140.1

129.4

123.3

119.6

110.7

93.6

68.9

18.2

1.0

0.1

VMAT

11.4

34.8

130.0

84.8

48.5

23.4

10.4

2.9

0.7

0.1

0.0

0.0

p-value

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

0.11

Femoral head left (mean volume 170.5 ccm)

3D-RT

26.5

46.3

141.9

131.4

125.1

121.6

114.3

98.8

72.9

17.3

0.8

0.0

VMAT

12.5

36.5

132.2

89.6

56.9

29.1

11.1

4.0

1.2

0.2

0.0

0.0

p-value

 < 0.01

 < 0.01

0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

 < 0.01

0.32

  1. Stated values are shown as mean values. Statistical analysis was performed using Wilcoxon signed rank test. A p-value < 0.05 was considered statistically significant. ccm = cubic centimeter, 3D-RT = 3D-conformal radiotherapy, VMAT = volumetric modulated arc therapy. Significant p-values are marked with bold.