Figure 3 | Scientific Reports

Figure 3

From: Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth

Figure 3

Lung tissue morphometric analysis. Parenchymal volume was lowest for heparin-treated mice compared to the remaining groups, although not reaching statistical significance (A). Alveolar volume was significantly lower in the heparin group compared to controls (B). Bivalirudin-treated mice also demonstrated lower alveolar volume. Septal surface area, which represents the area available for gas exchange, was significantly lower in heparin mice (C). Bivalirudin and argatroban did not significantly impact septal surface area. Alveolar density was significantly lower in the heparin and argatroban groups compared to controls (D). Bivalirudin did not significantly change alveolar density. Representative micrographs of hematoxylin and eosin-stained lung sections at 200 × magnification (E) demonstrate the decrease in alveolarization in heparin-treated mice compared to the control, bivalirudin, and argatroban groups. Statistical analysis of the experimental groups was done using analysis of variance (ANOVA), with Dunnett’s adjustment for multiple comparisons. Shown are mean ± standard error. *P < 0.05; ***P < 0.001.

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