Table 2 Shows 11 out of 43 proteolysis associated genes that are implicated in male reproduction.
From: Disruption of male fertility-critical Dcaf17 dysregulates mouse testis transcriptome
Gene | Function/Phenotype | Reference |
|---|---|---|
Prss37 | Serine protease, defective sperm migration and sperm-egg interaction | |
Prss55 | Serine protease, defective sperm migration in utero | |
Adam1a | Zinc metalloprotease, defective sperm migration in utero | |
Adam24 | Metalloproteinase on sperm surface, polyspermic embryos at the pronuclear stage resulting in reduced fertility | |
Adam26a | Thought to play a role in spermatogenesis | |
Cops5 | protease subunit of COP9 signalosome complex, acts as the catalytic center of the de-neddylation activity of cullins. Mutation leas to embryo growth arrest | |
Mmel1 | Metalloendopeptidase, deficiency leads to impaired fertilization and aberrant embryo development | |
Immp2l | Inner mitochondrial membrane peptidase 2-like is required for signal peptide sequence processing of proteins that require mitochondrial import. The mutated gene disturbs the inner mitochondrial proteostasis and results in female and male infertility | |
Sppl2c | Signal peptide peptidase. Disruption leads to a partial loss of elongated spermatids, reduced motility and reduced litter sizes when mated with Sppl2c deficient female | |
Psma6 | Component of the 20S core proteasome complex, has also been associated with low fertility | |
Usp1 | De-ubiquitinating enzyme causes amongst others Fanconi anemia (chromosome instability), which implicates infertility of male mice |
