Figure 2
From: Association between control group therapy and magnitude of clinical benefit of cancer drugs
Types of control group therapy. (A) Of 174 RCTs analyzed, 70% had an active therapy and 30% had non-active therapy in the control arm. Among RCTs with active therapy in the control arm, 28% were matched placebo (e.g., active therapy plus placebo in the control arm vs. the same active therapy plus an additional drug in the experimental arm). (B) Active therapy group was defined as control arm comprising an active anticancer drug such as chemotherapy, hormone therapy, immunotherapy and/or targeted therapy and non-active therapy group was defined as control arm comprising placebo and/or best supportive care alone. Other = Granulocyte–macrophage colony-stimulating factor. RCTs Randomized Controlled Trials.
