Figure 4

Mutations of FAT1 in pan-cancer. (A) Location of FAT1 in the chromosome. (B) Mutation of FAT1 in different tumors, “Deep Deletion”, indicates a deep loss, possibly a homozygous deletion, and “Amplification” indicates a high-level amplification (more copies, often focal). (C) General overview of FAT1 mutations in pan-cancer, with nodes and annotations representing different mutation profiles. (D) FAT1 mutation in UCEC predicts a good prognosis for patients, but in HNSC, it predicts a worse prognosis. (E) General overview of FAT mutations in the TMB and immunotherapy (MSKCC, Nat Genet 2019) dataset, with nodes and annotations representing different mutation profiles. (F) FAT1 mutations in the TMB and immunotherapy (MSKCC, Nat Genet 2019) dataset are predicted to have a better prognosis.