Table 2 Incidence of COVID-19 after post exposure prophylaxis with HCQ and placebo.

From: The ‘myth of Hydroxychloroquine (HCQ) as post-exposure prophylaxis (PEP) for the prevention of COVID-19’ is far from reality

Outcomes

Placebo/Control group (N = 594)

PEP/HCQ group (N = 574)

P value

COVID-19 * (N = 51)

27 (4.5%)

24 (4.2%)

0.761

Definite COVID-19 α (N = 37)

21 (3.5%)

16 (2.8%)

0.466

Probable COVID-19 β (N = 14)

6 (1.0%)

8 (1.4%)

0.547

New onset symptoms (N = 41)

24 (4.0%)

17 (3.0%)

0.317

Moderate to severe COVID-19

0

0

-

  1. *The participant with either definite or probable COVID-19 was defined as COVID-19 case.
  2. Total absolute risk reduction was -0.3% points and number needed to treat (NNT) was 333.3 with relative risk of 0.91 (95% confidence interval, 0.52 to 1.60).
  3. αThe participant with RTPCR positive for SARS-CoV-2 and with or without symptoms was defined as definite COVID-19 case.
  4. Total absolute risk reduction was -0.7% points and the NNT was 143 with relative risk of 0.78 (95% confidence interval, 0.40 to 1.51).
  5. βThe participant with new onset COVID-19 related symptoms but RTPCR negative for SARS-CoV-2 or could not be performed for any reason was defined as probable COVID-19 case.
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