Figure 1

Comparisons for analysis of differential DNAme associated with SSRI exposure and maternal depression in the discovery cohort. (A) The SSRI model investigates SSRI exposure in the full cohort (n = 64), comparing SSRI-exposed (n = 20) to SSRI non-exposed (n = 44) cases, adjusting for mean maternal Hamilton Depression score across gestation. (B) The SSRIs in maternal depression model investigates SSRI exposure in all maternally-depressed cases (mean maternal Hamilton Depression score > 8, n = 34), this model compares SSRI-exposed, maternally depressed cases (n = 14) to SSRI non-exposed, maternally depressed cases (n = 20). (C) The maternal depression without SSRIs model investigates the effect of maternal depression in cases not exposed to SSRIs (n = 44), this model compares SSRI non-exposed, maternally depressed cases (n = 20) to SSRI non-exposed and not maternally depressed cases (n = 24).