Figure 2
From: Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy
Volcano plots for differential DNAme in association with SSRI exposure and categorical depression. For all plots HamD refers to the mean maternal Hamilton Depression score across gestation for each individual. False discovery rate (FDR) is shown along the Y axis with more significant (lower FDR) values at the top of the plot. Vertical dashed intercepts demarcate |Δβ| = 0.03, horizontal dashed intercepts indicate, from top to bottom, FDR = 0.05, FDR = 0.15, and FDR = 0.25. (A) Volcano plot for the SSRI model, investigating differential DNAme associated with SSRI exposure adjusted for mean maternal HamD score, (n = 64). Difference in DNAme (Δβ) is plotted along the X axis and was calculated as Δβ = βSSRI-exposed – βSSRI non-exposed. (B) Volcano plot for the SSRIs in maternal depression model, differential DNAme associated with SSRI exposure in cases with mean maternal HamD score > 8, (n = 34). Difference in DNAme (Δβ) is plotted along the X axis and was calculated as Δβ = βSSRI-exposed – βSSRI non-exposed. (C) Volcano plot for the maternal depression without SSRIs model, differential DNAme associated HamD score > 8 across gestation, in SSRI non-exposed cases, (n = 44). Difference in DNAme (Δβ) is plotted along the X axis and was calculated as Δβ = βHamilton > 8 – βHamilton ≤ 8, “Depr” indicates “Depressed”, i.e. HamD > 8.
